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Thousands of novel translated open reading frames in humans inferred by ribosome footprint profiling

Accurate annotation of protein coding regions is essential for understanding how genetic information is translated into function. We describe riboHMM, a new method that uses ribosome footprint data to accurately infer translated sequences. Applying riboHMM to human lymphoblastoid cell lines, we iden...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Raj, Anil, Wang, Sidney H, Shim, Heejung, Harpak, Arbel, Li, Yang I, Engelmann, Brett, Stephens, Matthew, Gilad, Yoav, Pritchard, Jonathan K
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940163/
https://ncbi.nlm.nih.gov/pubmed/27232982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13328
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