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Thousands of novel translated open reading frames in humans inferred by ribosome footprint profiling

Accurate annotation of protein coding regions is essential for understanding how genetic information is translated into function. We describe riboHMM, a new method that uses ribosome footprint data to accurately infer translated sequences. Applying riboHMM to human lymphoblastoid cell lines, we iden...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Raj, Anil, Wang, Sidney H, Shim, Heejung, Harpak, Arbel, Li, Yang I, Engelmann, Brett, Stephens, Matthew, Gilad, Yoav, Pritchard, Jonathan K
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940163/
https://ncbi.nlm.nih.gov/pubmed/27232982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13328
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