Thousands of novel translated open reading frames in humans inferred by ribosome footprint profiling

Accurate annotation of protein coding regions is essential for understanding how genetic information is translated into function. We describe riboHMM, a new method that uses ribosome footprint data to accurately infer translated sequences. Applying riboHMM to human lymphoblastoid cell lines, we iden...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Raj, Anil, Wang, Sidney H, Shim, Heejung, Harpak, Arbel, Li, Yang I, Engelmann, Brett, Stephens, Matthew, Gilad, Yoav, Pritchard, Jonathan K
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2016
Gaiak:
Computational and Systems Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940163/
https://ncbi.nlm.nih.gov/pubmed/27232982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13328
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