Structural and mechanistic insights into the CRISPR inhibition of AcrIF7

The CRISPR–Cas system provides adaptive immunity for bacteria and archaea to combat invading phages and plasmids. Phages evolved anti-CRISPR (Acr) proteins to neutralize the host CRISPR–Cas immune system as a counter-defense mechanism. AcrIF7 in Pseudomonas aeruginosa prophages strongly inhibits the...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Kim, Iktae, Koo, Jasung, An, So Young, Hong, Suji, Ka, Donghyun, Kim, Eun-Hee, Bae, Euiyoung, Suh, Jeong-Yong
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515697/
https://ncbi.nlm.nih.gov/pubmed/32810226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa690
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