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Natural product inspired optimization of a selective TRPV6 calcium channel inhibitor
Transient receptor potential vanilloid 6 (TRPV6) is a calcium channel implicated in multifactorial diseases and overexpressed in numerous cancers. We recently reported the phenyl-cyclohexyl-piperazine cis-22a as the first submicromolar TRPV6 inhibitor. This inhibitor showed a seven-fold selectivity...
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| Publicado no: | RSC Med Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7513592/ https://ncbi.nlm.nih.gov/pubmed/33479695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00145g |
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