Inactivation-mimicking block of the epithelial calcium channel TRPV6

Epithelial calcium channel TRPV6 plays vital roles in calcium homeostasis, and its dysregulation is implicated in multifactorial diseases, including cancers. Here, we study the molecular mechanism of selective nanomolar-affinity TRPV6 inhibition by (4-phenylcyclohexyl)piperazine derivatives (PCHPDs)...

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Detalles Bibliográficos
Publicado en:Sci Adv
Main Authors: Bhardwaj, Rajesh, Lindinger, Sonja, Neuberger, Arthur, Nadezhdin, Kirill D., Singh, Appu K., Cunha, Micael R., Derler, Isabella, Gyimesi, Gergely, Reymond, Jean-Louis, Hediger, Matthias A., Romanin, Christoph, Sobolevsky, Alexander I.
Formato: Artigo
Idioma:Inglês
Publicado: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7695471/
https://ncbi.nlm.nih.gov/pubmed/33246965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe1508
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