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Inactivation-mimicking block of the epithelial calcium channel TRPV6
Epithelial calcium channel TRPV6 plays vital roles in calcium homeostasis, and its dysregulation is implicated in multifactorial diseases, including cancers. Here, we study the molecular mechanism of selective nanomolar-affinity TRPV6 inhibition by (4-phenylcyclohexyl)piperazine derivatives (PCHPDs)...
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| Publicado en: | Sci Adv |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Association for the Advancement of Science
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7695471/ https://ncbi.nlm.nih.gov/pubmed/33246965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe1508 |
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