Frequency and clinicopathologic profile of PIK3CA mutant GISTs: molecular genetic study of 529 cases

Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors usually driven by the mutational activation of receptor tyrosine kinases, KIT, or PDGFRA. Oncogenic activation of phosphatidylinositide-3-kinase (PI3K), a downstream effector in the KIT signaling pathway, has been identified in different...

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Detalhes bibliográficos
Publicado no:Mod Pathol
Main Authors: Lasota, Jerzy, Felisiak-Golabek, Anna, Wasag, Bartosz, Kowalik, Artur, Zięba, Sebastian, Chłopek, Małgorzata, Wang, Zeng-Feng, Coates, Tiffany, Kopczynski, Janusz, Gozdz, Stanislaw, Sarlomo-Rikala, Maarit, Miettinen, Markku
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7511989/
https://ncbi.nlm.nih.gov/pubmed/26796526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/modpathol.2015.160
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