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New Mechanisms of mTOR Pathway Activation in KIT-mutant Malignant GISTs
A great majority of gastrointestinal stromal tumors (GISTs) are primarily driven by gain-of-function KIT receptor tyrosine kinase mutations that subsequently lead to activation of phosphatidiylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway, a downstream effector of KIT signali...
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| Udgivet i: | Appl Immunohistochem Mol Morphol |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8191381/ https://ncbi.nlm.nih.gov/pubmed/28777148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PAI.0000000000000541 |
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