Inhibition of radiation-induced skin fibrosis with imatinib

PURPOSE: Dermal fibrosis is a disabling late toxicity of radiotherapy. Several lines of evidence suggest that overactive signaling via the Platelet-derived growth factor receptor-beta (PDGFR-β) and V-abl Abelson murine leukemia viral oncogene homolog 1 (cAbl) may be etiologic factors in the developm...

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Bibliografske podrobnosti
izdano v:Int J Radiat Biol
Main Authors: Horton, JasonA., Chung, Eun Joo, Hudak, Kathryn E., Sowers, Anastasia, Thetford, Angela, White, Ayla O., Mitchell, James B., Citrin, Deborah E.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7511984/
https://ncbi.nlm.nih.gov/pubmed/23083077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/09553002.2013.741281
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