Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice

Cdc42 is a small RhoGTPase regulating multiple functions in eukaryotic cells. The activity of Cdc42 is significantly elevated in several tissues of aged mice, while the Cdc42 gain‐of‐activity mouse model presents with a premature aging‐like phenotype and with decreased lifespan. These data suggest a...

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Publicat a:Aging Cell
Autors principals: Florian, Maria Carolina, Leins, Hanna, Gobs, Michael, Han, Yang, Marka, Gina, Soller, Karin, Vollmer, Angelika, Sakk, Vadim, Nattamai, Kalpana J., Rayes, Ahmad, Zhao, Xueheng, Setchell, Kenneth, Mulaw, Medhanie, Wagner, Wolfgang, Zheng, Yi, Geiger, Hartmut
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Short Take
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7511875/
https://ncbi.nlm.nih.gov/pubmed/32755011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13208
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