Aging alters the epigenetic asymmetry of HSC division

Hematopoietic stem cells (HSCs) balance self-renewal and differentiation to maintain homeostasis. With aging, the frequency of polar HSCs decreases. Cell polarity in HSCs is controlled by the activity of the small RhoGTPase cell division control protein 42 (Cdc42). Here we demonstrate—using a compre...

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Udgivet i:PLoS Biol
Main Authors: Florian, M. Carolina, Klose, Markus, Sacma, Mehmet, Jablanovic, Jelena, Knudson, Luke, Nattamai, Kalpana J., Marka, Gina, Vollmer, Angelika, Soller, Karin, Sakk, Vadim, Cabezas-Wallscheid, Nina, Zheng, Yi, Mulaw, Medhanie A., Glauche, Ingmar, Geiger, Hartmut
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168157/
https://ncbi.nlm.nih.gov/pubmed/30235201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2003389
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