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Aging alters the epigenetic asymmetry of HSC division
Hematopoietic stem cells (HSCs) balance self-renewal and differentiation to maintain homeostasis. With aging, the frequency of polar HSCs decreases. Cell polarity in HSCs is controlled by the activity of the small RhoGTPase cell division control protein 42 (Cdc42). Here we demonstrate—using a compre...
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| Publicado no: | PLoS Biol |
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| Main Authors: | , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6168157/ https://ncbi.nlm.nih.gov/pubmed/30235201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2003389 |
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