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Cooperative hetero-ligands interaction with G-quadruplexes shows evidence of allosteric binding
Although allosteric binding of small molecules is commonplace in protein structures, it is rather rare in DNA species such as G-quadruplexes. By using CD melting, here, we found binding of the small-molecule ligands PDS and L2H2–6OTD to the telomeric DNA G-quadruplex was cooperative. Mass spectromet...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7511437/ https://ncbi.nlm.nih.gov/pubmed/32833433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00351 |
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