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A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands
Ligands that stabilize the formation of telomeric DNA G-quadruplexes have potential as cancer treatments, because the G-quadruplex structure cannot be extended by telomerase, an enzyme over-expressed in many cancer cells. Understanding the kinetic, thermodynamic and mechanical properties of small-mo...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3277938/ https://ncbi.nlm.nih.gov/pubmed/21941250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.1126 |
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