Self-Reporting Transposons Enable Simultaneous Readout of Gene Expression and Transcription Factor Binding in Single Cells

Cellular heterogeneity confounds in situ assays of transcription factor (TF) binding. Single-cell RNA sequencing (scRNA-seq) deconvolves cell types from gene expression, but no technology links cell identity to TF binding sites (TFBS) in those cell types. We present self-reporting transposons (SRTs)...

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Библиографические подробности
Опубликовано в: :Cell
Главные авторы: Moudgil, Arnav, Wilkinson, Michael N., Chen, Xuhua, He, June, Cammack, Alexander J., Vasek, Michael J., Lagunas, Tomás, Qi, Zongtai, Lalli, Matthew A., Guo, Chuner, Morris, Samantha A., Dougherty, Joseph D., Mitra, Robi D.
Формат: Artigo
Язык:Inglês
Опубликовано: 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7510185/
https://ncbi.nlm.nih.gov/pubmed/32710817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.06.037
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