Brd4-bound enhancers drive cell-intrinsic sex differences in glioblastoma

Sex can be an important determinant of cancer phenotype, and exploring sex-biased tumor biology holds promise for identifying novel therapeutic targets and new approaches to cancer treatment. In an established isogenic murine model of glioblastoma (GBM), we discovered correlated transcriptome-wide s...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kfoury, Najla, Qi, Zongtai, Prager, Briana C., Wilkinson, Michael N., Broestl, Lauren, Berrett, Kristopher C., Moudgil, Arnav, Sankararaman, Sumithra, Chen, Xuhua, Gertz, Jason, Rich, Jeremy N., Mitra, Robi D., Rubin, Joshua B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8072233/
https://ncbi.nlm.nih.gov/pubmed/33850013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2017148118
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