Self-Reporting Transposons Enable Simultaneous Readout of Gene Expression and Transcription Factor Binding in Single Cells

Cellular heterogeneity confounds in situ assays of transcription factor (TF) binding. Single-cell RNA sequencing (scRNA-seq) deconvolves cell types from gene expression, but no technology links cell identity to TF binding sites (TFBS) in those cell types. We present self-reporting transposons (SRTs)...

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Udgivet i:Cell
Main Authors: Moudgil, Arnav, Wilkinson, Michael N., Chen, Xuhua, He, June, Cammack, Alexander J., Vasek, Michael J., Lagunas, Tomás, Qi, Zongtai, Lalli, Matthew A., Guo, Chuner, Morris, Samantha A., Dougherty, Joseph D., Mitra, Robi D.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7510185/
https://ncbi.nlm.nih.gov/pubmed/32710817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.06.037
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