Self-Reporting Transposons Enable Simultaneous Readout of Gene Expression and Transcription Factor Binding in Single Cells

Cellular heterogeneity confounds in situ assays of transcription factor (TF) binding. Single-cell RNA sequencing (scRNA-seq) deconvolves cell types from gene expression, but no technology links cell identity to TF binding sites (TFBS) in those cell types. We present self-reporting transposons (SRTs)...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell
Egile Nagusiak: Moudgil, Arnav, Wilkinson, Michael N., Chen, Xuhua, He, June, Cammack, Alexander J., Vasek, Michael J., Lagunas, Tomás, Qi, Zongtai, Lalli, Matthew A., Guo, Chuner, Morris, Samantha A., Dougherty, Joseph D., Mitra, Robi D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7510185/
https://ncbi.nlm.nih.gov/pubmed/32710817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.06.037
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