Amino acid depletion triggered by ʟ-asparaginase sensitizes MM cells to carfilzomib by inducing mitochondria ROS-mediated cell death

Metabolic reprogramming is emerging as a cancer vulnerability that could be therapeutically exploitable using different approaches, including amino acid depletion for those tumors that rely on exogenous amino acids for their maintenance. ʟ-Asparaginase (ASNase) has contributed to a significant impro...

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Veröffentlicht in:Blood Adv
Hauptverfasser: Soncini, Debora, Minetto, Paola, Martinuzzi, Claudia, Becherini, Pamela, Fenu, Valeria, Guolo, Fabio, Todoerti, Katia, Calice, Giovanni, Contini, Paola, Miglino, Maurizio, Rivoli, Giulia, Aquino, Sara, Dominietto, Alida, Cagnetta, Antonia, Passalacqua, Mario, Bruzzone, Santina, Nencioni, Alessio, Zucchetti, Massimo, Ceruti, Tommaso, Neri, Antonino, Lemoli, Roberto M., Cea, Michele
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2020
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7509874/
https://ncbi.nlm.nih.gov/pubmed/32915979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001639
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