A novel vitamin D gene therapy for acute myeloid leukemia

Current treatment approaches for older adult patients with acute myeloid leukemia (AML) are often toxic and lack efficacy. Active vitamin D3 (1,25(OH)(2)D3) has been shown to induce myeloid blast differentiation but at concentrations that have resulted in unacceptable, off-target hypercalcemia in cl...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Transl Oncol
Autori principali: Xu, Yi, Payne, Kimberly, Pham, Linh Hoang Gia, Eunwoo, Park, Xiao, Jeffrey, Chi, David, Lyu, Justin, Campion, Rosalia, Wasnik, Samiksha, Jeong, Il Seok, Tang, Xiaolei, Baylink, David Jeston, Chen, Chien Shing, Reeves, Mark, Akhtari, Mojtaba, Mirshahidi, Saied, Marcucci, Guido, Cao, Huynh
Natura: Artigo
Lingua:Inglês
Pubblicazione: Neoplasia Press 2020
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7509076/
https://ncbi.nlm.nih.gov/pubmed/32956997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2020.100869
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