Novel B55α-PP2A mutations in AML promote AKT T308 phosphorylation and sensitivity to AKT inhibitor-induced growth arrest

Activation of the Protein Kinase B (PKB), or AKT pathway has been shown to correlate with acute myeloid leukemia (AML) prognosis. B55α-Protein Phosphatase 2A (PP2A) has been shown to dephosphorylate AKT at Thr-308 rendering it inactive. In fact, low expression of the PP2A regulatory subunit B55α was...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Shouse, Geoffrey, de Necochea-Campion, Rosalia, Mirshahidi, Saied, Liu, Xuan, Chen, Chien-Shing
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308637/
https://ncbi.nlm.nih.gov/pubmed/27531894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11209
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