Autophagic flux inhibition enhances cytotoxicity of the receptor tyrosine kinase inhibitor ponatinib

BACKGROUND: Despite reported advances, acquired resistance to tyrosine kinase inhibitors still represents a serious problem in successful cancer treatment. Among this class of drugs, ponatinib (PON) has been shown to have notable long-term efficacy, although its cytotoxicity might be hampered by aut...

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Publicat a:J Exp Clin Cancer Res
Autors principals: Corallo, Diana, Pastorino, Fabio, Pantile, Marcella, Mariotto, Elena, Caicci, Federico, Viola, Giampietro, Ponzoni, Mirco, Tonini, Gian Paolo, Aveic, Sanja
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7507635/
https://ncbi.nlm.nih.gov/pubmed/32962733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01692-x
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