HDAC inhibitors tune miRNAs in extracellular vesicles of dystrophic muscle‐resident mesenchymal cells

We show that extracellular vesicles (EVs) released by mesenchymal cells (i.e., fibro–adipogenic progenitors—FAPs) mediate microRNA (miR) transfer to muscle stem cells (MuSCs) and that exposure of dystrophic FAPs to HDAC inhibitors (HDACis) increases the intra‐EV levels of a subset of miRs, which coo...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Sandonà, Martina, Consalvi, Silvia, Tucciarone, Luca, De Bardi, Marco, Scimeca, Manuel, Angelini, Daniela Francesca, Buffa, Valentina, D'Amico, Adele, Bertini, Enrico Silvio, Cazzaniga, Sara, Bettica, Paolo, Bouché, Marina, Bongiovanni, Antonella, Puri, Pier Lorenzo, Saccone, Valentina
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7507515/
https://ncbi.nlm.nih.gov/pubmed/32754983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202050863
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