HDAC inhibitors tune miRNAs in extracellular vesicles of dystrophic muscle‐resident mesenchymal cells

We show that extracellular vesicles (EVs) released by mesenchymal cells (i.e., fibro–adipogenic progenitors—FAPs) mediate microRNA (miR) transfer to muscle stem cells (MuSCs) and that exposure of dystrophic FAPs to HDAC inhibitors (HDACis) increases the intra‐EV levels of a subset of miRs, which coo...

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Bibliografski detalji
Izdano u:EMBO Rep
Glavni autori: Sandonà, Martina, Consalvi, Silvia, Tucciarone, Luca, De Bardi, Marco, Scimeca, Manuel, Angelini, Daniela Francesca, Buffa, Valentina, D'Amico, Adele, Bertini, Enrico Silvio, Cazzaniga, Sara, Bettica, Paolo, Bouché, Marina, Bongiovanni, Antonella, Puri, Pier Lorenzo, Saccone, Valentina
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7507515/
https://ncbi.nlm.nih.gov/pubmed/32754983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202050863
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