HDAC inhibitors tune miRNAs in extracellular vesicles of dystrophic muscle‐resident mesenchymal cells

We show that extracellular vesicles (EVs) released by mesenchymal cells (i.e., fibro–adipogenic progenitors—FAPs) mediate microRNA (miR) transfer to muscle stem cells (MuSCs) and that exposure of dystrophic FAPs to HDAC inhibitors (HDACis) increases the intra‐EV levels of a subset of miRs, which coo...

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Publicat a:EMBO Rep
Autors principals: Sandonà, Martina, Consalvi, Silvia, Tucciarone, Luca, De Bardi, Marco, Scimeca, Manuel, Angelini, Daniela Francesca, Buffa, Valentina, D'Amico, Adele, Bertini, Enrico Silvio, Cazzaniga, Sara, Bettica, Paolo, Bouché, Marina, Bongiovanni, Antonella, Puri, Pier Lorenzo, Saccone, Valentina
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7507515/
https://ncbi.nlm.nih.gov/pubmed/32754983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202050863
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