Connexin26 mediates CO(2)-dependent regulation of breathing via glial cells of the medulla oblongata

Breathing is highly sensitive to the PCO(2) of arterial blood. Although CO(2) is detected via the proxy of pH, CO(2) acting directly via Cx26 may also contribute to the regulation of breathing. Here we exploit our knowledge of the structural motif of CO(2)-binding to Cx26 to devise a dominant negati...

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Detalhes bibliográficos
Publicado no:Commun Biol
Main Authors: van de Wiel, Joseph, Meigh, Louise, Bhandare, Amol, Cook, Jonathan, Nijjar, Sarbjit, Huckstepp, Robert, Dale, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7505967/
https://ncbi.nlm.nih.gov/pubmed/32958814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01248-x
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