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Connexin26 mediates CO(2)-dependent regulation of breathing via glial cells of the medulla oblongata

Breathing is highly sensitive to the PCO(2) of arterial blood. Although CO(2) is detected via the proxy of pH, CO(2) acting directly via Cx26 may also contribute to the regulation of breathing. Here we exploit our knowledge of the structural motif of CO(2)-binding to Cx26 to devise a dominant negati...

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Bibliografski detalji
Izdano u:Commun Biol
Glavni autori: van de Wiel, Joseph, Meigh, Louise, Bhandare, Amol, Cook, Jonathan, Nijjar, Sarbjit, Huckstepp, Robert, Dale, Nicholas
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7505967/
https://ncbi.nlm.nih.gov/pubmed/32958814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01248-x
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