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Altered CO (2) sensitivity of connexin26 mutant hemichannels in vitro

Connexin26 (Cx26) mutations underlie human pathologies ranging from hearing loss to keratitis ichthyosis deafness (KID) syndrome. Cx26 hemichannels are directly gated by CO (2) and contribute to the chemosensory regulation of breathing. The KID syndrome mutation A88V is insensitive to CO (2), and ha...

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Bibliografiska uppgifter
I publikationen:Physiol Rep
Huvudupphovsmän: de Wolf, Elizabeth, van de Wiel, Joseph, Cook, Jonathan, Dale, Nicholas
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2016
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357999/
https://ncbi.nlm.nih.gov/pubmed/27884957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13038
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