Genome-wide alterations of uracil distribution patterns in human DNA upon chemotherapeutic treatments

Numerous anti-cancer drugs perturb thymidylate biosynthesis and lead to genomic uracil incorporation contributing to their antiproliferative effect. Still, it is not yet characterized if uracil incorporations have any positional preference. Here, we aimed to uncover genome-wide alterations in uracil...

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Detaylı Bibliyografya
Yayımlandı:eLife
Asıl Yazarlar: Pálinkás, Hajnalka L, Békési, Angéla, Róna, Gergely, Pongor, Lőrinc, Papp, Gábor, Tihanyi, Gergely, Holub, Eszter, Póti, Ádám, Gemma, Carolina, Ali, Simak, Morten, Michael J, Rothenberg, Eli, Pagano, Michele, Szűts, Dávid, Győrffy, Balázs, Vértessy, Beáta G
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications, Ltd 2020
Konular:
Chromosomes and Gene Expression
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7505663/
https://ncbi.nlm.nih.gov/pubmed/32956035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60498
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