CRISPR/Cas9-Mediated Knock-Out of dUTPase in Mice Leads to Early Embryonic Lethality

Sanitization of nucleotide pools is essential for genome maintenance. Deoxyuridine 5′-triphosphate nucleotidohydrolase (dUTPase) is a key enzyme in this pathway since it catalyzes the cleavage of 2′-deoxyuridine 5′-triphosphate (dUTP) into 2′-deoxyuridine 5′-monophosphate (dUMP) and inorganic pyroph...

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Bibliografiske detaljer
Udgivet i:	Biomolecules
Main Authors:	Pálinkás, Hajnalka Laura, Rácz, Gergely Attila, Gál, Zoltán, Hoffmann, Orsolya Ivett, Tihanyi, Gergely, Róna, Gergely, Gócza, Elen, Hiripi, László, Vértessy, Beáta G.
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI 2019
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6523736/ https://ncbi.nlm.nih.gov/pubmed/30987342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9040136
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CRISPR/Cas9-Mediated Knock-Out of dUTPase in Mice Leads to Early Embryonic Lethality

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