Genome-wide alterations of uracil distribution patterns in human DNA upon chemotherapeutic treatments

Numerous anti-cancer drugs perturb thymidylate biosynthesis and lead to genomic uracil incorporation contributing to their antiproliferative effect. Still, it is not yet characterized if uracil incorporations have any positional preference. Here, we aimed to uncover genome-wide alterations in uracil...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Pálinkás, Hajnalka L, Békési, Angéla, Róna, Gergely, Pongor, Lőrinc, Papp, Gábor, Tihanyi, Gergely, Holub, Eszter, Póti, Ádám, Gemma, Carolina, Ali, Simak, Morten, Michael J, Rothenberg, Eli, Pagano, Michele, Szűts, Dávid, Győrffy, Balázs, Vértessy, Beáta G
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Chromosomes and Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7505663/
https://ncbi.nlm.nih.gov/pubmed/32956035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60498
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