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An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells

The Ras/PI3K/ERK signaling network plays fundamental roles in cell growth, survival, and migration and is frequently activated in cancer. Here we show that the activities of the signaling network propagate as coordinated waves, biased by growth factor, which drive actin-based protrusions in human ep...

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Bibliographische Detailangaben
Veröffentlicht in:Dev Cell
Hauptverfasser: Zhan, Huiwang, Bhattacharya, Sayak, Cai, Huaqing, Iglesias, Pablo A., Huang, Chuan-Hsiang, Devreotes, Peter N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7505206/
https://ncbi.nlm.nih.gov/pubmed/32877650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2020.08.001
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