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An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells

The Ras/PI3K/ERK signaling network plays fundamental roles in cell growth, survival, and migration and is frequently activated in cancer. Here we show that the activities of the signaling network propagate as coordinated waves, biased by growth factor, which drive actin-based protrusions in human ep...

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Détails bibliographiques
Publié dans:Dev Cell
Auteurs principaux: Zhan, Huiwang, Bhattacharya, Sayak, Cai, Huaqing, Iglesias, Pablo A., Huang, Chuan-Hsiang, Devreotes, Peter N.
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7505206/
https://ncbi.nlm.nih.gov/pubmed/32877650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2020.08.001
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