Mutually inhibitory Ras-PI(3,4)P(2) feedback loops mediate cell migration

Signal transduction and cytoskeleton networks in a wide variety of cells display excitability, but the mechanisms are poorly understood. Here, we show that during random migration and in response to chemoattractants, cells maintain complementary spatial and temporal distributions of Ras activity and...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Li, Xiaoguang, Edwards, Marc, Swaney, Kristen F., Singh, Nilmani, Bhattacharya, Sayak, Borleis, Jane, Long, Yu, Iglesias, Pablo A., Chen, Jie, Devreotes, Peter N.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166812/
https://ncbi.nlm.nih.gov/pubmed/30194235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1809039115
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