Mutually inhibitory Ras-PI(3,4)P(2) feedback loops mediate cell migration

Signal transduction and cytoskeleton networks in a wide variety of cells display excitability, but the mechanisms are poorly understood. Here, we show that during random migration and in response to chemoattractants, cells maintain complementary spatial and temporal distributions of Ras activity and...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Li, Xiaoguang, Edwards, Marc, Swaney, Kristen F., Singh, Nilmani, Bhattacharya, Sayak, Borleis, Jane, Long, Yu, Iglesias, Pablo A., Chen, Jie, Devreotes, Peter N.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2018
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166812/
https://ncbi.nlm.nih.gov/pubmed/30194235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1809039115
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