Analysis of β(2)AR-G(s) and β(2)AR-G(i) complex formation by NMR spectroscopy

The β(2)-adrenergic receptor (β(2)AR) is a prototypical G protein-coupled receptor (GPCR) that preferentially couples to the stimulatory G protein G(s) and stimulates cAMP formation. Functional studies have shown that the β(2)AR also couples to inhibitory G protein G(i), activation of which inhibits...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ma, Xiuyan, Hu, Yunfei, Batebi, Hossein, Heng, Jie, Xu, Jun, Liu, Xiangyu, Niu, Xiaogang, Li, Hongwei, Hildebrand, Peter W., Jin, Changwen, Kobilka, Brian K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7502740/
https://ncbi.nlm.nih.gov/pubmed/32868434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2009786117
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