Two Classes of Cholesterol Binding Sites for the β(2)AR Revealed by Thermostability and NMR

Cholesterol binding to G protein-coupled receptors (GPCRs) and modulation of their activities in membranes is a fundamental issue for understanding their function. Despite the identification of cholesterol binding sites in high-resolution x-ray structures of the β(2) adrenergic receptor (β(2)AR) and...

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Detalles Bibliográficos
Publicado en:Biophys J
Main Authors: Gater, Deborah L., Saurel, Olivier, Iordanov, Iordan, Liu, Wei, Cherezov, Vadim, Milon, Alain
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2014
Assuntos:
Membranes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4241438/
https://ncbi.nlm.nih.gov/pubmed/25418299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.10.011
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