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Selective profiling of N- and C-terminal nucleotide-binding sites in a TRPM2 channel
Transient receptor potential melastatin 2 (TRPM2) is a homotetrameric Ca(2+)-permeable cation channel important for the immune response, body temperature regulation, and insulin secretion, and is activated by cytosolic Ca(2+) and ADP ribose (ADPR). ADPR binds to two distinct locations, formed by lar...
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| Publié dans: | J Gen Physiol |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Rockefeller University Press
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7201885/ https://ncbi.nlm.nih.gov/pubmed/32211872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201912533 |
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