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Simple binding of protein kinase A prior to phosphorylation allows CFTR anion channels to be opened by nucleotides
The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) anion channel is essential for epithelial salt–water balance. CFTR mutations cause cystic fibrosis, a lethal incurable disease. In cells CFTR is activated through the cAMP signaling pathway, overstimulation of which during cholera leads...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7474675/ https://ncbi.nlm.nih.gov/pubmed/32817533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2007910117 |
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