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The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity
Transient Receptor Potential Melastatin 2 (TRPM2) is a Ca(2+)-permeable cation channel essential for immunocyte activation, insulin secretion, and postischemic cell death. TRPM2 is activated by ADP ribose (ADPR) binding to its C-terminal cytosolic NUDT9-homology (NUDT9H) domain, homologous to the so...
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| Udgivet i: | eLife |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
eLife Sciences Publications, Ltd
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4974056/ https://ncbi.nlm.nih.gov/pubmed/27383051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17600 |
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