Enzyme activity and selectivity filter stability of ancient TRPM2 channels were simultaneously lost in early vertebrates

Transient Receptor Potential Melastatin 2 (TRPM2) is a cation channel important for the immune response, insulin secretion, and body temperature regulation. It is activated by cytosolic ADP ribose (ADPR) and contains a nudix-type motif 9 (NUDT9)-homology (NUDT9-H) domain homologous to ADPR phosphohy...

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Veröffentlicht in:eLife
Hauptverfasser: Iordanov, Iordan, Tóth, Balázs, Szollosi, Andras, Csanády, László
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2019
Schlagworte:
Structural Biology and Molecular Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461439/
https://ncbi.nlm.nih.gov/pubmed/30938679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44556
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