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Simple binding of protein kinase A prior to phosphorylation allows CFTR anion channels to be opened by nucleotides
The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) anion channel is essential for epithelial salt–water balance. CFTR mutations cause cystic fibrosis, a lethal incurable disease. In cells CFTR is activated through the cAMP signaling pathway, overstimulation of which during cholera leads...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7474675/ https://ncbi.nlm.nih.gov/pubmed/32817533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2007910117 |
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