Inhibition of acid ceramidase regulates MHC class II antigen presentation and suppression of autoimmune arthritis

The bioactive sphingolipid ceramide affects immune responses although its effect on antigen (Ag) processing and delivery by HLA class II to CD4+ T-cells remains unclear. Therefore, we examined the actions of a novel cell-permeable acid ceramidase (AC) inhibitor [(1R,2R) N myristoylamino-(4′-nitrophe...

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Foilsithe in:Cytokine
Main Authors: Zhao, Dan, Hajiaghamohseni, Laela M., Liu, Xiang, Szulc, Zdzislaw M., Bai, Aiping, Bielawska, Alicja, Norris, James S., Reddy, Sakamuri V., Hannun, Yusuf A., Haque, Azizul
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2020
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7502491/
https://ncbi.nlm.nih.gov/pubmed/32738771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cyto.2020.155219
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