The membrane-associated form of cyclin D1 enhances cellular invasion

The essential G(1)-cyclin, CCND1, is a collaborative nuclear oncogene that is frequently overexpressed in cancer. D-type cyclins bind and activate CDK4 and CDK6 thereby contributing to G(1)–S cell-cycle progression. In addition to the nucleus, herein cyclin D1 was also located in the cytoplasmic mem...

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Veröffentlicht in:Oncogenesis
Hauptverfasser: Chen, Ke, Jiao, Xuanmao, Ashton, Anthony, Di Rocco, Agnese, Pestell, Timothy G., Sun, Yunguang, Zhao, Jun, Casimiro, Mathew C., Li, Zhiping, Lisanti, Michael P., McCue, Peter A., Shen, Duanwen, Achilefu, Samuel, Rui, Hallgeir, Pestell, Richard G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7501870/
https://ncbi.nlm.nih.gov/pubmed/32948740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-020-00266-y
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