Four-octyl itaconate activates Nrf2 cascade to protect osteoblasts from hydrogen peroxide-induced oxidative injury

Four-octyl itaconate (4-OI) is the cell-permeable derivative of itaconate that can activate Nrf2 signaling by alkylating Keap1’s cysteine residues. Here, we tested the potential effect of 4-OI on hydrogen peroxide (H(2)O(2))-induced oxidative injury in osteoblasts. In OB-6 cells and primary murine o...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Cell Death Dis
Autores principales: Zheng, Yuehuan, Chen, Zhe, She, Chang, Lin, Yazhou, Hong, Yuan, Shi, Liqiang, Zhang, Yingzi, Cao, Peng, Xu, Xiangyang
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7499214/
https://ncbi.nlm.nih.gov/pubmed/32943614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02987-9
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares