Octyl itaconate inhibits osteoclastogenesis by suppressing Hrd1 and activating Nrf2 signaling

The endogenous metabolite itaconate has emerged as a regulator of macrophage function that limits inflammation. However, its effect on cell differentiation and osteoclast-related diseases is unclear. Here, for the first time, we explored the effect of itaconate and its cell-permeable itaconate deriv...

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Библиографические подробности
Опубликовано в: :FASEB J
Главные авторы: Sun, Xuewu, Zhang, Boya, Pan, Xin, Huang, Hai, Xie, Ziang, Ma, Yan, Hu, Bin, Wang, Jiying, Chen, Zhijun, Shi, Peihua
Формат: Artigo
Язык:Inglês
Опубликовано: Federation of American Societies for Experimental Biology 2019
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6902740/
https://ncbi.nlm.nih.gov/pubmed/31490085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900887RR
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