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Four-octyl itaconate activates Nrf2 cascade to protect osteoblasts from hydrogen peroxide-induced oxidative injury
Four-octyl itaconate (4-OI) is the cell-permeable derivative of itaconate that can activate Nrf2 signaling by alkylating Keap1’s cysteine residues. Here, we tested the potential effect of 4-OI on hydrogen peroxide (H(2)O(2))-induced oxidative injury in osteoblasts. In OB-6 cells and primary murine o...
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| Publicado no: | Cell Death Dis |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7499214/ https://ncbi.nlm.nih.gov/pubmed/32943614 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02987-9 |
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