Reduction in Dynamics of Base pair Opening upon Ligand Binding by the Cocaine-Binding Aptamer

We have used magnetization transfer NMR experiments to measure the exchange rate constant (k(ex)) of the imino protons in the unbound, cocaine-bound, and quinine-bound forms of the cocaine-binding DNA aptamer. Both long-stem 1 (MN4) and short-stem 1 (MN19) variants were analyzed, corresponding to st...

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Bibliographic Details
Published in:Biophys J
Main Authors: Churcher, Zachary R., Garaev, Devid, Hunter, Howard N., Johnson, Philip E.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2020
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7499103/
https://ncbi.nlm.nih.gov/pubmed/32882188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.08.012
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