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Reduction in Dynamics of Base pair Opening upon Ligand Binding by the Cocaine-Binding Aptamer
We have used magnetization transfer NMR experiments to measure the exchange rate constant (k(ex)) of the imino protons in the unbound, cocaine-bound, and quinine-bound forms of the cocaine-binding DNA aptamer. Both long-stem 1 (MN4) and short-stem 1 (MN19) variants were analyzed, corresponding to st...
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| Publicado no: | Biophys J |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7499103/ https://ncbi.nlm.nih.gov/pubmed/32882188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.08.012 |
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