Post-mortem analyses of PiB and flutemetamol in diffuse and cored amyloid-β plaques in Alzheimer’s disease

Specificity and sensitivity of positron emission tomography (PET) radiopharmaceuticals targeting fibrillar amyloid-β (Aβ) deposits is high for detection of neuritic Aβ plaques, a mature form of Aβ deposits which often have dense Aβ core (i.e., cored plaques). However, imaging-to-autopsy validation s...

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Bibliographic Details
Published in:Acta Neuropathol
Main Authors: Ikonomovic, Milos D., Buckley, Christopher J., Abrahamson, Eric E., Kofler, Julia K., Mathis, Chester A., Klunk, William E., Farrar, Gill
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2020
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7498488/
https://ncbi.nlm.nih.gov/pubmed/32772265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-020-02175-1
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