FANCJ compensates for RAP80 deficiency and suppresses genomic instability induced by interstrand cross-links

FANCJ, a DNA helicase and interacting partner of the tumor suppressor BRCA1, is crucial for the repair of DNA interstrand crosslinks (ICL), a highly toxic lesion that leads to chromosomal instability and perturbs normal transcription. In diploid cells, FANCJ is believed to operate in homologous reco...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Awate, Sanket, Sommers, Joshua A, Datta, Arindam, Nayak, Sumeet, Bellani, Marina A, Yang, Olivia, Dunn, Christopher A, Nicolae, Claudia M, Moldovan, George-Lucian, Seidman, Michael M, Cantor, Sharon B, Brosh, Robert M
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7498338/
https://ncbi.nlm.nih.gov/pubmed/32797166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa660
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados