FANCJ compensates for RAP80 deficiency and suppresses genomic instability induced by interstrand cross-links

FANCJ, a DNA helicase and interacting partner of the tumor suppressor BRCA1, is crucial for the repair of DNA interstrand crosslinks (ICL), a highly toxic lesion that leads to chromosomal instability and perturbs normal transcription. In diploid cells, FANCJ is believed to operate in homologous reco...

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Bibliografski detalji
Izdano u:Nucleic Acids Res
Glavni autori: Awate, Sanket, Sommers, Joshua A, Datta, Arindam, Nayak, Sumeet, Bellani, Marina A, Yang, Olivia, Dunn, Christopher A, Nicolae, Claudia M, Moldovan, George-Lucian, Seidman, Michael M, Cantor, Sharon B, Brosh, Robert M
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Genome Integrity, Repair and Replication
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7498338/
https://ncbi.nlm.nih.gov/pubmed/32797166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa660
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