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Nucleosomes effectively shield DNA from radiation damage in living cells

Eukaryotic DNA is organized in nucleosomes, which package DNA and regulate its accessibility to transcription, replication, recombination and repair. Here, we show that in living cells nucleosomes protect DNA from high-energy radiation and reactive oxygen species. We combined sequence-based methods...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Brambilla, Francesca, Garcia-Manteiga, Jose Manuel, Monteleone, Emanuele, Hoelzen, Lena, Zocchi, Angelica, Agresti, Alessandra, Bianchi, Marco E
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7498322/
https://ncbi.nlm.nih.gov/pubmed/32710624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa613
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