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Nucleosomes effectively shield DNA from radiation damage in living cells

Eukaryotic DNA is organized in nucleosomes, which package DNA and regulate its accessibility to transcription, replication, recombination and repair. Here, we show that in living cells nucleosomes protect DNA from high-energy radiation and reactive oxygen species. We combined sequence-based methods...

詳細記述

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書誌詳細
出版年:Nucleic Acids Res
主要な著者: Brambilla, Francesca, Garcia-Manteiga, Jose Manuel, Monteleone, Emanuele, Hoelzen, Lena, Zocchi, Angelica, Agresti, Alessandra, Bianchi, Marco E
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7498322/
https://ncbi.nlm.nih.gov/pubmed/32710624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa613
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