Nucleosome dynamics: HMGB1 relaxes canonical nucleosome structure to facilitate estrogen receptor binding

High mobility group protein 1 (HMGB1) interacts with DNA and chromatin to influence the regulation of transcription, DNA repair and recombination. We show that HMGB1 alters the structure and stability of the canonical nucleosome (N) in a nonenzymatic, ATP-independent manner. Although estrogen recept...

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Bibliografiska uppgifter
Huvudupphovsmän: Joshi, Sachindra R., Sarpong, Yaw C., Peterson, Ronald C., Scovell, William M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2012
Ämnen:
Gene Regulation, Chromatin and Epigenetics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488250/
https://ncbi.nlm.nih.gov/pubmed/22941653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks815
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